STIMULATION OF PROLIFERATION BY 3,3',5-TRIIODO-L-THYRONINE IN POORLY DIFFERENTIATED HUMAN HEPATOCARCINOMA CELLS OVEREXPRESSING BETA-1 THYROID-HORMONE RECEPTOR

被引：27
|
作者：
LIN, KH [1 ]
LIN, YW [1 ]
PARKISON, C [1 ]
CHENG, SY [1 ]
机构：
[1] NCI,DCBDC,MOLEC BIOL LAB,BETHESDA,MD 20892
来源：
CANCER LETTERS | 1994年 / 85卷 / 02期
关键词：
THYROID HORMONE; T-3; RECEPTOR; CARCINOGENESIS; HEPATOCARCINOMA; GROWTH AND DIFFERENTIATION;
D O I：
10.1016/0304-3835(94)90274-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To understand the role of thyroid hormone nuclear receptors (TRs) in hepatocarcinogenesis, we characterized the TRs in nine human hepatocarcinoma cell lines. The expression of TR proteins is receptor subtype- and cell type dependent. TR alpha 1 protein expresses similarly at a low level in each of the nine cell lines. In contrast, TR beta 1 is overexpressed in hepatocarcinoma cells which are poorly differentiated. Furthermore, thyroid hormone was found to stimulate the proliferation of cells in which TR beta 1 is overexpressed. These results suggest that TR beta 1 is most likely involved in the differentiation and proliferation of hepatocarcinoma cells. Our studies have shed new light in the understanding of the role of TRs in liver carcinogenesis.
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页码：189 / 194
页数：6
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