ARABIDOPSIS ASSAY FOR MUTAGENICITY

被引：21
作者：
GICHNER, T
BADAYEV, SA
DEMCHENKO, SI
RELICHOVA, J
SANDHU, SS
USMANOV, PD
USMANOVA, O
VELEMINSKY, J
机构：
[1] MOSCOW CHEM PHYS INST, MOSCOW, RUSSIA
[2] FAC SCI BRNO, DEPT GENET, BRNO, CZECH REPUBLIC
[3] US EPA, RES TRIANGLE PK, NC 27711 USA
[4] TAJIK ACAD SCI, DEPT GENET, DUSHANBE, TAJIKISTAN
来源：
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1994年 / 310卷 / 02期
关键词：
IPCS COLLABORATIVE STUDY; ARABIDOPSIS THALIANA; EMBRYONIC AND CHLOROPHYLL MUTANTS; ETHYL METHANESULFONATE; N-METHYL-N-NITROSOUREA; AZIDOGLYCEROL; MALEIC HYDRAZIDE; SODIUM AZIDE;
D O I：
10.1016/0027-5107(94)90117-1
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Four laboratories, two in the Czech Republic (Brno and Prague) and two in the CIS (Moscow and Duschanbe), participated in the International Programme on Chemical Safety's (IPCS) collaborative study to evaluate the utility of the most commonly used plant test systems, including the Arabidopsis thaliana assay, for assessing the mutagenic potential of environmental agents. Out of the five compounds evaluated in the Arabidopsis assay, three compounds, i.e., ethyl methanesulfonate, N-methyl-N-nitrosourea, and azidoglycerol, were reported to be mutagenic by all four participating laboratories. Sodium azide (NaN3) demonstrated a negative response in all four laboratories, whereas maleic hydrazide was reported to be weakly mutagenic by one laboratory and nonmutagenic by the other three laboratories.
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页码：249 / 256
页数：8
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