ENZYMATIC-SYNTHESIS OF (6R)-FLUOROSHIKIMIC ACID AND (6S)-FLUOROSHIKIMIC ACID

被引：24

作者：

DUGGAN, PJ

PARKER, E

COGGINS, J

ABELL, C

机构：

[1] UNIV CAMBRIDGE,CHEM LAB,CAMBRIDGE CB2 1EW,ENGLAND

[2] UNIV GLASGOW,DEPT BIOCHEM,GLASGOW G12 8QQ,LANARK,SCOTLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 20期

关键词：

D O I：

10.1016/0960-894X(95)00405-I

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

6-Fluoroshikimates have interesting antibiotic properties. The enzymatic preparation of (6R)- and (6S)-fluoroshikimates from 3-fluorophosphoenolpyruvate is described. The multistep enzymatic conversion is followed by UV and F-19 NMR spectroscopy.

引用

页码：2347 / 2352

页数：6

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