ELECTROCHEMICAL STUDY OF THE NITRO RADICAL-ANION FROM NICARDIPINE - KINETIC-PARAMETERS AND ITS INTERACTION WITH GLUTATHIONE

The cyclic voltammetric behavior of nicardipine was studied. Particular attention was directed to the one-electron ArNO2/ArNO2.- couple as measured by the cyclic voltammetric mode in aqueous DMF mixed media. Analysis of this response as a function of scan rate yields information on the stability of the nitro radical anion. A second-order rate constant k(2) = 174 l mol(-1) s(-1) for the decomposition of the nitro radical anion from nicardipine and a half-life of 1.15 s were obtained. The cyclic voltammetric technique was also employed to study the tendency of ArNO2.- to undergo further chemical reaction; specific attention was paid to the interaction with glutathione.