CHEMOENZYMATIC SYNTHESIS OF C-13-LABELED S-(-)-MALIC ACID

被引：0

作者：

HILLNER, AC ^{[1
]}

JANS, AWH ^{[1
]}

WINKEL, C ^{[1
]}

机构：

[1] MAX PLANCK INST SYST PHYSIOL,RHEINLANDDAMM 201,W-4600 DORTMUND,GERMANY

来源：

JOURNAL FUR PRAKTISCHE CHEMIE-CHEMIKER-ZEITUNG | 1993年 / 335卷 / 04期

关键词：

D O I：

10.1002/prac.19933350405

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The first regio- and stereospecific synthesis of S-(-)-C-13-malic acid 5 with a high incorporation of C-13 and excellent enantiomeric excess is described. S-(-)-C-13-malic acid 5 was synthesized in a three-step reaction starting with ethyl acetate 2 and diethyl oxalate 1. The produced sodium diethyl oxaloacetate 3 was then enantioselectively reduced with bakers' yeast to S-(-)-C-13-malic acid diethylester 4 which was hydrolyzed to S-(-)-C-13-malic acid 5.

引用

页码：332 / 336

页数：5

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