RECIPROCAL MODULATION OF CORTICOTROPIN-RELEASING FACTOR AND INTERLEUKIN-1 RECEPTORS FOLLOWING ETHER-LAPAROTOMY STRESS IN THE MOUSE

被引：10

作者：

TAKAO, T ^{[1
]}

TOJO, C ^{[1
]}

NISHIOKA, T ^{[1
]}

KUROKAWA, H ^{[1
]}

TAKEMURA, T ^{[1
]}

HASHIMOTO, K ^{[1
]}

DESOUZA, EB ^{[1
]}

机构：

[1] NEUROCRINE BIOSCI,SAN DIEGO,CA 92121

来源：

BRAIN RESEARCH | 1994年 / 660卷 / 01期

关键词：

CRF RECEPTOR; IL-1; RECEPTOR; STRESS; ACTH; HPA AXIS;

D O I：

10.1016/0006-8993(94)90853-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ether-laparotomy stress resulted in a dramatic decrease in specific iodine-125-labeled ovine CRF binding ([I-125]oCRF) in the pituitary at 6 h after the onset of the stress although it did not affect [I-125]oCRF binding in the pituitary at 2 h after the stress. [I-125]oCRF binding was unchanged in the frontal cortex after the stress. In contrast, [I-125]interleukin-1 (IL-1)alpha binding was significantly increased in the pituitary at 2 h after the stress and tended to be higher than non-stressed levels at 6 h after the stress but was not statistically significant. Ether-laparotomy stress did not affect [I-125]IL-1 alpha binding in hippocampus, spleen and testis at any time after the stress. Plasma adrenocorticotropic hormone (ACTH) and corticosterone were increased at 2 h after the stress. These data demonstrate complex interactions between CRF and IL-1 receptors on HPA axis during stress.

引用

页码：170 / 174

页数：5

共 33 条

[11] EFFECTS OF RECOMBINANT HUMAN INTERLEUKIN-1-ALPHA, INTERLEUKIN-1-BETA, 2 AND 6 ON ACTH SYNTHESIS AND RELEASE IN THE MOUSE PITUITARY-TUMOR CELL-LINE ATT-20 [J].