NEUROPEPTIDES IN MIGRAINE AND CLUSTER HEADACHE

被引：167
作者：
EDVINSSON, L [1 ]
GOADSBY, PJ [1 ]
机构：
[1] UNIV NEW S WALES, PRINCE HENRY HOSP, DEPT NEUROL, KENSINGTON, NSW 2033, AUSTRALIA
来源：
CEPHALALGIA | 1994年 / 14卷 / 05期
关键词：
D O I：
10.1046/j.1468-2982.1994.1405320.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The cerebral circulation is invested by a rich network of neuropeptide Y (NPY) and noradrenaline containing sympathetic nerve fibers in arteries, arterioles and veins. However, the nerve supply of vasoactive intestinal peptide (VIP), substance P (SP) and calcitonin gene-related peptide (CGRP) containing fibers is sparse. While noradrenaline and NPY cause vasoconstriction, VIP, SP and CGRP are potent vasodilators. Stimulation of the trigeminal ganglion in cat and man elicits release of SP and CGRP. Subjects with spontaneous attacks of migraine show release of CGRP in parallel with headache. Cluster headache patients have release of CGRP and VIP during bouts. Treatment with sumatriptan aborts headache in migraine and cluster headache as well as the concomitant peptide release.
引用
收藏
页码：320 / 327
页数：8
相关论文
共 50 条
[31]   CONTROLLED TRIALS OF CIMETIDINE IN MIGRAINE AND CLUSTER HEADACHE [J].
ANTHONY, M ;
LORD, GDA ;
LANCE, JW .
HEADACHE, 1978, 18 (05) :261-264
[32]   Unilateral headaches beyond migraine and cluster headache [J].
Seidel, S. ;
Lieba-Samal, D. ;
Vigl, M. ;
Woeber, C. .
CEPHALALGIA, 2009, 29 :45-45
[33]   Biomarkers of Migraine and Cluster Headache: Differences and Similarities [J].
Messina, Roberta ;
Sudre, Carole H. ;
Wei, Diana Y. ;
Filippi, Massimo ;
Ourselin, Sebastien ;
Goadsby, Peter J. .
ANNALS OF NEUROLOGY, 2023, 93 (04) :729-742
[34]   Plasma levels of orexin - A in migraine and cluster headache [J].
Hamada, J. ;
Sakai, F. ;
Yonekura, Junko .
CEPHALALGIA, 2007, 27 (06) :620-621
[35]   Neurostimulation for the treatment of chronic migraine and cluster headache [J].
Cvetkovic, Vlasta Vukovic ;
Jensen, Rigmor H. .
ACTA NEUROLOGICA SCANDINAVICA, 2019, 139 (01) :4-17
[36]   Noonan syndrome associated with migraine and cluster headache [J].
Grozeva, Veselina ;
Miguel Lainez, Jose .
CEPHALALGIA, 2017, 37 :235-235
[37]   THE EFFECT OF INFUSED PROSTACYCLIN IN MIGRAINE AND CLUSTER HEADACHE [J].
PEATFIELD, RC ;
GAWEL, MJ ;
ROSE, FC .
HEADACHE, 1981, 21 (05) :190-195
[38]   Intranasal Medications for the Treatment of Migraine and Cluster Headache [J].
Alan M. Rapoport ;
Marcelo E. Bigal ;
Stewart J. Tepper ;
Fred D. Sheftell .
CNS Drugs, 2004, 18 :671-685
[39]   Quality of life determinants in cluster headache and migraine [J].
Bozsik, G ;
Manhalter, N ;
Ertsey, C .
CEPHALALGIA, 2005, 25 (08) :654-654
[40]   VERAPAMIL (ISOPTIN) IN THE TREATMENT OF MIGRAINE AND CLUSTER HEADACHE [J].
KOZUBSKI, W .
NEW TRENDS IN CLINICAL NEUROPHARMACOLOGY: CALCIUM ANATONISTS, ACUTE NEUROLOGY, HEADACHE AND MOVEMENT DISORDERS, 1988, 7 :23-26
12345