NEUROPEPTIDES IN MIGRAINE AND CLUSTER HEADACHE

被引：167
作者：
EDVINSSON, L [1 ]
GOADSBY, PJ [1 ]
机构：
[1] UNIV NEW S WALES, PRINCE HENRY HOSP, DEPT NEUROL, KENSINGTON, NSW 2033, AUSTRALIA
来源：
CEPHALALGIA | 1994年 / 14卷 / 05期
关键词：
D O I：
10.1046/j.1468-2982.1994.1405320.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The cerebral circulation is invested by a rich network of neuropeptide Y (NPY) and noradrenaline containing sympathetic nerve fibers in arteries, arterioles and veins. However, the nerve supply of vasoactive intestinal peptide (VIP), substance P (SP) and calcitonin gene-related peptide (CGRP) containing fibers is sparse. While noradrenaline and NPY cause vasoconstriction, VIP, SP and CGRP are potent vasodilators. Stimulation of the trigeminal ganglion in cat and man elicits release of SP and CGRP. Subjects with spontaneous attacks of migraine show release of CGRP in parallel with headache. Cluster headache patients have release of CGRP and VIP during bouts. Treatment with sumatriptan aborts headache in migraine and cluster headache as well as the concomitant peptide release.
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页码：320 / 327
页数：8
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