Using Genetic Algorithms to Explore Pattern Recognition in the Immune System

被引：142

作者：

Forrest, Stephanie ^{[1
]}

Javornik, Brenda ^{[1
]}

Smith, Robert E. ^{[2
]}

Perelson, Alan S. ^{[3
]}

机构：

[1] Univ New Mexico, Dept Comp Sci, Albuquerque, NM 87131 USA

[2] Univ Alabama, Dept Engn Mech, Tuscaloosa, AL 35487 USA

[3] Univ Calif Los Alamos Natl Lab, Div Theoret, Los Alamos, NM 87545 USA

来源：

EVOLUTIONARY COMPUTATION | 1993年 / 1卷 / 03期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

genetic algorithms; immune system; pattern recognition; fitness sharing;

D O I：

10.1162/evco.1993.1.3.191

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

This paper describes an immune system model based on binary strings. The purpose of the model is to study the pattern-recognition processes and learning that take place at both the individual and species levels in the immune system. The genetic algorithm (GA) is a central component of the model. The paper reports simulation experiments on two-pattern-recognition problems that are relevant to natural immune systems. Finally, it reviews the relation between the model and explicit fitness-sharing techniques for genetic algorithms, showing that the immune system model implements a form of implicit fitness sharing.

引用

页码：191 / 211

页数：21

共 17 条

[11]

Holland J.H., 1992, ADAPTATION NATURAL A, V2nd ed.

[12]

Inman J., 1978, THEORETICAL IMMUNOLO

[13] PREDICTING THE SIZE OF THE T-CELL RECEPTOR AND ANTIBODY COMBINING REGION FROM CONSIDERATION OF EFFICIENT SELF NONSELF DISCRIMINATION [J].

PERCUS, JK ;

PERCUS, OE ;

PERELSON, AS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (05) :1691-1695

[14] IMMUNE NETWORK THEORY [J].

PERELSON, AS .

IMMUNOLOGICAL REVIEWS, 1989, 110 :5-36

[15] THEORETICAL-STUDIES OF CLONAL SELECTION - MINIMAL ANTIBODY REPERTOIRE SIZE AND RELIABILITY OF SELF-NON-SELF DISCRIMINATION [J].

PERELSON, AS ;

OSTER, GF .

JOURNAL OF THEORETICAL BIOLOGY, 1979, 81 (04) :645-670

[16] Searching for Diverse, Cooperative Populations with Genetic Algorithms [J].

Smith, Robert E. ;

Forrest, Stephanie ;

Perelson, Alan S. .

EVOLUTIONARY COMPUTATION, 1993, 1 (02) :127-149

[17]

Stadnyk I., 1987, P 2 INT C GEN ALG TH

← 1 2 →