ANTITUMOR-PROMOTING ACTIVITIES OF HYDROLYZABLE TANNINS IN MOUSE SKIN

被引：62

作者：

GALI, HU ^{[1
]}

PERCHELLET, EM ^{[1
]}

KLISH, DS ^{[1
]}

JOHNSON, JM ^{[1
]}

PERCHELLET, JP ^{[1
]}

机构：

[1] KANSAS STATE UNIV AGR & APPL SCI,DIV BIOL,ANTICANC DRUG LAB,MANHATTAN,KS 66506

来源：

CARCINOGENESIS | 1992年 / 13卷 / 04期

关键词：

D O I：

10.1093/carcin/13.4.715

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ellagic acid and gallic acid and its derivatives, applied topically to female CF-1 mice 20 min before each 12-0-tetra-decanoylphorbol-13-acetate (TPA) treatment inhibit the inductions of epidermal ornithine decarboxylase activity, hydroperoxide production and DNA synthesis caused by this potent tumor promoter in relation with their abilities to inhibit the promotion of skin papillomas and carcinomas in the two-step initiation - promotion protocol. Because of its potency against TPA promotion, tannic acid, which is already known to inhibit tumor initiation, may inhibit the multistage process of carcinogenesis.

引用

页码：715 / 718

页数：4

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