ESSENTIAL ROLE OF NITRIC-OXIDE IN DESCENDING INHIBITION IN THE RAT PROXIMAL COLON

被引：109

作者：

HATA, F

ISHII, T

KANADA, A

YAMANO, N

KATAOKA, T

TAKEUCHI, T

YAGASAKI, O

机构：

[1] Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefectural University, Sakai

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)91605-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Possible mediators of descending inhibition in the rat proximal colon were studied. Localized distension with a small balloon caused relaxation of the circular muscle on the anal side of the distended region. This relaxation was still observed after the colonic segment had been desensitized to ATP, neurotensin and vasoactive intestinal peptide, so these compounds seem unlikely to mediate descending inhibition. Nitro-arginine inhibited the relaxation induced by the distension, and L-arginine counteracted the effect of nitro-arginine. Nitric oxide, isoamylnitrate and sodium nitroprusside caused relaxation. These results strongly suggest an essential role of nitric oxide in descending relaxation in the rat proximal colon. © 1990.

引用

页码：1400 / 1406

页数：7

共 33 条

[1]

AMBACHE N, 1977, BRIT J PHARMACOL, V61, pP113

[2] VASOACTIVE INTESTINAL POLYPEPTIDE - A PUTATIVE TRANSMITTER IN THE CANINE GASTRIC MUSCULARIS MUCOSA [J].