FORMATION OF SINGLET MOLECULAR-OXYGEN BY 8-METHOXYPSORALEN

被引：76
作者：
DEMOL, NJ
BEIJERSBERGENVANHENEGOUW.GM
机构：
[1] Gorlaeus Laboratories, Department of Pharmacochemistry, State University, Leyden
来源：
PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1979年 / 30卷 / 03期
关键词：
D O I：
10.1111/j.1751-1097.1979.tb07364.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Abstract— The formation of singlet molecular oxygen (lO2) by energy transfer from the excited 8‐meth‐oxypsoralen (8‐MOP) molecule was investigated. This was done in several ways: (a) In the reaction of irradiated 8‐MOP with the 1O2 acceptor 2‐methyl‐2‐pentene, the characteristic oxidation products were identified. (b) The rate of the 8‐MOP sensitized photooxidation of 3, 4‐dihydroxy phenylalanine (dopa), which appeared to be also a useful 1O2 acceptor, was larger in D2O than in H2O. (c) The β‐values for reaction of 1O2with dopa in the presence of 8‐MOP or of methylene blue as 1O2 generators were in accordance with each other. The consequences of 1O2 formation by 8‐MOP sensitization is discussed for the clinical use of this compound. Copyright © 1979, Wiley Blackwell. All rights reserved
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页码：331 / 335
页数：5
相关论文
共 48 条
[31]   PHOTOCHEMOTHERAPY OF VITILIGO - USE OF ORALLY-ADMINISTERED PSORALENS AND A HIGH-INTENSITY LONG-WAVE ULTRAVIOLET-LIGHT SYSTEM [J].
PARRISH, JA ;
FITZPATRICK, TB ;
SHEA, C ;
PATHAK, MA .
ARCHIVES OF DERMATOLOGY, 1976, 112 (11) :1531-1534
[32]   FACTORS REGULATING GROWTH AND PIGMENTATION OF MELANOMA CELLS [J].
PAWELEK, JM .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1976, 66 (04) :201-209
[33]   PHOTODYNAMIC SENSITIZATION BY 8-METHOXYPSORALEN VIA SINGLET OXYGEN MECHANISM [J].
POPPE, W ;
GROSSWEINER, LI .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1975, 22 (05) :217-219
[34]   PHOTO-OXIDE OF 1,3-DIPHENYLISOBENZOFURAN [J].
RIO, G ;
SCHOLL, MJ .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1975, (12) :474-475
[35]   BIOCHEMICAL AND MEDICAL ASPECTS OF PSORALENS [J].
RODIGHIERO, G ;
DALLACQUA, F .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1976, 24 (06) :647-653
[36]   RECENT DEVELOPMENTS IN SINGLET MOLECULAR-OXYGEN CHEMISTRY [J].
ROSENTHAL, I .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1976, 24 (06) :641-645
[37]  
Sehgal V N, 1975, Int J Dermatol, V14, P205
[38]   INHIBITION OF MELANIN FORMATION BY SULFHYDRYL COMPOUNDS [J].
SEIJI, M ;
YOSHIDA, T ;
ITAKURA, H ;
IRIMAJIRI, T .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1969, 52 (03) :280-+
[39]   SINGLET OXYGEN - MAJOR REACTIVE SPECIES IN FUROCOUMARIN PHOTOSENSITIZED INACTIVATION OF ESCHERICHIA-COLI RIBOSOMES [J].
SINGH, H ;
VADASZ, JA .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1978, 28 (4-5) :539-545
[40]   LUMINESCENCE SPECTRA AND PHOTOCYCLOADDITION OF EXCITED COUMARINS TO DNA BASES [J].
SONG, PS ;
HARTER, ML ;
MOORE, TA ;
HERNDON, WC .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1971, 14 (04) :521-+
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