CALCIUM-CHANNEL BLOCKERS AND OTHER FACTORS INFLUENCING DELAYED FUNCTION IN RENAL-ALLOGRAFTS

A retrospective analysis was undertaken to examine the influence of calcium-channel blocking drugs on early renal allograft function. Delayed function was denned as the need for dialysis or a reduction in serum creatinine of less than 15% within 4 days of transplantation. The drug histories of 172 patients were examined. After exclusions, the data from 138 patients were analysed. No patient was taking any calcium-channel blocking drug other than nifedipine. Thirty-one patients were taking nifedipine at the time of transplantation and these had a delayed function rate of 16% compared with 40% for 107 patients not taking nifedipine (I2, P<0.05). Delayed function occurred in 61% of cases when the donor age was over 50 years compared with 29% with younger donors (I2, P<0.05). A total ischaemic time of longer than 24 h and administration of inotropic support to the donor were associated with delayed function (I2, P<0.05). Administration to the donor of mannitol, steroids, phenoxybenzamine and heparin had no effect on the rate of delayed function. Recipients treated with low-dose dopamine in the perioperative period had no advantage. Elevated trough whole blood concentrations of cyclosporin in the first week after transplant were associated with delayed function (Mann-Whitney U, P<0.05). © 1990 European Dialysis and Transplant Association-European Renal Association.