EFFECT OF GRADED ADRENALINE INFUSION ON ARTERIAL ADRENALINE CLEARANCE IN NORMOTENSIVE AND HYPERTENSIVE MAN

被引：4
作者：
BACHMANN, AW [1 ]
GORDON, RD [1 ]
BATHGATE, RAD [1 ]
THOMPSON, RE [1 ]
机构：
[1] UNIV QUEENSLAND, GREENSLOPES HOSP, DEPT MED, ENDOCRINE HYPERTENS RES UNIT, BRISBANE, QLD 4120, AUSTRALIA
来源：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1990年 / 17卷 / 04期
关键词：
adrenaline; adrenaline clearance; adrenaline infusion; arterial; blood pressure; essential hypertensives; heart rate; normotensives;
D O I：
10.1111/j.1440-1681.1990.tb01317.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. Arterial adrenaline (ADR) levels were measured during graded ADR infusions in normotensives (NT) and in mild hypertensives (HT), in order to test the hypothesis that ADR enhances its own clearance in NT. 2. Although infusion of ADR resulted in similar arterial ADR levels in NT and HT, increases in systolic blood pressure (SBP) and heart rate (HR) and decreases in diastolic blood pressure (DBP) were greater during ADR infusion in HT than in NT. 3. Twenty minutes after cessation of infusion, SBP and HR remained elevated in HT but not in NT. 4. No evidence was found supporting enhanced ADR clearance during increasing ADR levels in NT or HT. Copyright © 1990, Wiley Blackwell. All rights reserved
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页码：257 / 261
页数：5
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