GENETIC-MAPPING IN THE REGION OF THE MOUSE X-INACTIVATION CENTER

被引：30
作者：
KEER, JT
HAMVAS, RMJ
BROCKDORFF, N
PAGE, D
RASTAN, S
BROWN, SDM
机构：
[1] ST MARYS HOSP,SCH MED,DEPT BIOCHEM & MOLEC GENET,LONDON W2 1PG,ENGLAND
[2] MRC,CLIN RES CTR,COMPARAT BIOL SECT,HARROW HA1 3UJ,MIDDX,ENGLAND
[3] MIT,WHITEHEAD INST,CAMBRIDGE,MA 02139
[4] MIT,DEPT BIOL,CAMBRIDGE,MA 02139
来源：
GENOMICS | 1990年 / 7卷 / 04期
基金：
美国国家卫生研究院; 英国医学研究理事会;
关键词：
D O I：
10.1016/0888-7543(90)90200-E
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The mouse X-inactivation center lies just distal to the T16H breakpoint. Utilizing pedigree analysis of backcross progeny from a Mus domesticus/Mus spretus interspecific cross, we have mapped a number of genetic loci, gene probes, microclones, and EagI linking clones distal to the T16H breakpoint. The genetic analysis provides a detailed genetic map in the vicinity of the mouse X-inactivation center. Comparative mapping data from the human X chromosome indicate that the most probable location of the mouse X-inactivation center is distal to Ccg-1 and in the region of the Pgk-1 locus. We report the assignment of two new loci, EM13 and DXSmh44, to the Ccg-1 Pgk-1 interval. © 1990.
引用
收藏
页码：566 / 572
页数：7
相关论文
共 32 条
  • [1] SPREADING OF INACTIVATION IN AN (X-14) TRANSLOCATION
    ALLDERDICE, PW
    MILLER, OJ
    MILLER, DA
    KLINGER, HP
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS, 1978, 2 (03): : 233 - 240
  • [2] MAPPING OF THE MOUSE X-CHROMOSOME USING RANDOM GENOMIC PROBES AND AN INTERSPECIFIC MOUSE CROSS
    AMAR, LC
    ARNAUD, D
    CAMBROU, J
    GUENET, JL
    AVNER, PR
    [J]. EMBO JOURNAL, 1985, 4 (13B) : 3695 - 3700
  • [3] CHARACTERIZATION OF A PANEL OF SOMATIC-CELL HYBRIDS FOR REGIONAL MAPPING OF THE MOUSE X-CHROMOSOME
    AVNER, P
    ARNAUD, D
    AMAR, L
    CAMBROU, J
    WINKING, H
    RUSSELL, LB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (15) : 5330 - 5334
  • [4] LOCALIZATION OF THE HUMAN X-LINKED GENE FOR CHRONIC GRANULOMATOUS-DISEASE TO THE MOUSE X-CHROMOSOME - IMPLICATIONS FOR X-CHROMOSOME EVOLUTION
    BROCKDORFF, N
    FISHER, EMC
    ORKIN, SH
    LYON, MF
    BROWN, SDM
    [J]. CYTOGENETICS AND CELL GENETICS, 1988, 48 (02): : 124 - 125
  • [5] CONSTRUCTION AND ANALYSIS OF LINKING LIBRARIES FROM THE MOUSE X-CHROMOSOME
    BROCKDORFF, N
    MONTAGUE, M
    SMITH, S
    RASTAN, S
    [J]. GENOMICS, 1990, 7 (04) : 573 - 578
  • [6] THE MAPPING OF A CDNA FROM THE HUMAN X-LINKED DUCHENNE MUSCULAR-DYSTROPHY GENE TO THE MOUSE X-CHROMOSOME
    BROCKDORFF, N
    CROSS, GS
    CAVANNA, JS
    FISHER, FMC
    LYON, MF
    DAVIES, KE
    BROWN, SDM
    [J]. NATURE, 1987, 328 (6126) : 166 - 168
  • [7] CONSTRUCTION OF A DETAILED MOLECULAR MAP OF THE MOUSE X-CHROMOSOME BY MICROCLONING AND INTERSPECIFIC CROSSES
    BROCKDORFF, N
    FISHER, EMC
    CAVANNA, JS
    LYON, MF
    BROWN, SDM
    [J]. EMBO JOURNAL, 1987, 6 (11) : 3291 - 3297
  • [8] REGIONAL LOCALIZATION OF CCG1 GENE WHICH COMPLEMENTS HAMSTER-CELL CYCLE MUTATION BN462 TO XQ11-XQ13
    BROWN, CJ
    SEKIGUCHI, T
    NISHIMOTO, T
    WILLARD, HF
    [J]. SOMATIC CELL AND MOLECULAR GENETICS, 1989, 15 (01) : 93 - 96
  • [9] BROWN CJ, 1989, CYTOGENET CELL GENET, V51, P971
  • [10] Cattanach B. M., 1989, MOUSE NEWS LETT, V83, P165
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