Pathological consequences of C-peptide deficiency in insulin-dependent diabetes mellitus

被引:20
作者
Ghorbani, Ahmad [1 ]
Shafiee-Nick, Reza [1 ,2 ]
机构
[1] Mashhad Univ Med Sci, Sch Med, Pharmacol Res Ctr Med Plants, Mashhad 913753316, Iran
[2] Mashhad Univ Med Sci, Sch Med, Dept Pharmacol, Mashhad 913753316, Iran
关键词
C-peptide; Diabetes; Insulin; Nephropathy; Neuropathy;
D O I
10.4239/wjd.v6.i1.145
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Diabetes is associated with several complications such as retinopathy, nephropathy, neuropathy and cardiovascular diseases. Currently, insulin is the main used medication for management of insulin-dependent diabetes mellitus (type-1 diabetes). In this metabolic syndrome, in addition to decrease of endogenous insulin, the plasma level of connecting peptide (C-peptide) is also reduced due to beta cell destruction. Studies in the past decade have shown that C-peptide is much more than a byproduct of insulin biosynthesis and possess different biological activities. Therefore, it may be possible that C-peptide deficiency be involved, at least in part, in the development of different complications of diabetes. It has been shown that a small level of remaining C-peptide is associated with significant metabolic benefit. The purpose of this review is to describe beneficial effects of C-peptide replacement on pathological features associated with insulin-dependent diabetes. Also, experimental and clinical findings on the effects of C-peptide on whole-body glucose utilization, adipose tissue metabolism and tissues blood flow are summarized and discussed. The hypoglycemic, antilipolytic and vasodilator effects of C-peptide suggest that it may contribute to fine-tuning of the tissues metabolism under different physiologic or pathologic conditions. Therefore, C-peptide replacement together with the classic insulin therapy may prevent, retard, or ameliorate diabetic complications in patients with type-1 diabetes.
引用
收藏
页码:145 / 150
页数:6
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