STABILITY OF AN AMIDE-HYDROGEN BOND IN AN APOLAR ENVIRONMENT

被引：65

作者：

KLOTZ, IM

FARNHAM, SB

机构：

[1] Biochemistry Division, Department of Chemistry, Northwestern University, Evanston, Illinois

来源：

BIOCHEMISTRY | 1968年 / 7卷 / 11期

关键词：

D O I：

10.1021/bi00851a013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Free-energy changes for dissociating an N-H ⋯ O=C bond to N-H (aqueous solution) and C=O (aqueous solution) are not significantly different if the initial amide-hydrogen bond is in an aqueous or an apolar solvent. Literature data lead to the same conclusion for O-H ⋯ O=C hydrogen bonds. Evidently the intrinsic interaction between donor and acceptor groups is not sensitive to the adjacent molecular environment. This is of interest in regard to unfolding of ordered protein conformations. © 1968, American Chemical Society. All rights reserved.

引用

页码：3879 / &

共 7 条

[1]

Christian S. D., 1963, J CHEM EDUC, V40, P419

[2] ROLE OF DISSOLVED WATER IN PARTITION EQUILIBRIA OF CARBOXYLIC ACIDS [J].