THIAMINE TRIPHOSPHATE DEFICIENCY IN SUBACUTE NECROTIZING ENCEPHALOMYELOPATHY

被引：103

作者：

COOPER, JR

ITOKAWA, Y

PINCUS, JH

机构：

[1] Department of Pharmacology, Section of Neurology, Yale University School of Medicine, New Haven, CT

来源：

SCIENCE | 1969年 / 164卷 / 3875期

关键词：

D O I：

10.1126/science.164.3875.74

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Extracts of tissue fluids from a patient with subacute necrotizing encephalomyelopathy inhibit thiamine pyrophosphate-adenosine triphosphate phosphotransferase of rat brain. Brain tissue from the patient, in contrast to normal brain tissue, contained essentially no thiamine triphosphate, although thiamine and its other phosphate esters were present in normal concentrations. These findings suggest a relation between this disease and thiamine triphosphate.

引用

页码：74 / &

共 14 条

[1]

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[2]

BERGMEYER HU, 1963, METHODS ENZYMATIC ED, P543

[3]

BERGMEYER HU, 1963, METHODS ENZYMATIC ED, P573

[4]

COOPER JACK R., 1967, CIBA FOUND STUDY GROUPIN THIAMINE DEFICIENCY BIOCHEMICAL LESIONS AND THEIR CLINICAL SIGNIFICANCE, V28, P112

[5] ROLE OF THIAMINE IN NERVOUS TISSUE - MECHANISM OF ACTION OF PYRITHIAMINE [J].