Tumour necrosis factor-alpha and adenosine in endotoxin shock-related cardiovascular symptoms

被引：7
作者：
Sipka, S
Seres, T
Dinya, Z
Szekanecz, Z
Szentmiklosi, J
Bodolay, E
Szegedi, G
机构：
[1] UNIV DEBRECEN,SCH MED,DEPT PHARMACOL,DEBRECEN,HUNGARY
[2] LAJOS KOSSUTH UNIV,DEPT ORGAN CHEM,H-4010 DEBRECEN,HUNGARY
来源：
MEDIATORS OF INFLAMMATION | 1995年 / 4卷 / 06期
关键词：
adenosine; endotoxin shock; tumour necrosis factor-alpha;
D O I：
10.1155/S0962935195000731
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
WE have observed uncontrollable cardiogenic shock as a cardiovascular manifestation of systemic inflammatory response syndrome (SIRS) leading to death in a 62-year-old woman. The diagnosis of SIRS was based on the demonstration of endotoxinaemia, and highly elevated plasma levels of tumour necrosis factor (TNF)-alpha, and interleukin (IL)-10. We suggest that these cytokines may contribute to the terminal SIRS-related arrythmias, impaired myocardial contractility, as well as increased vascular permeability. In addition the increased production of adenosine, a counter-regulatory mediator of inflammation may also play a role in cardiodepression. We suggest a relationship between the action of TNF-alpha, IL-10 and adenosine in the pathogenesis of circulatory symptoms described above.
引用
收藏
页码：454 / 455
页数：2
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