INTRAMOLECULAR PD-CATALYZED ARYL-ENONE CONJUGATE ADDITIONS - CONTROL OF REDUCTIVE VS NONREDUCTIVE CYCLIZATION

被引：63

作者：

FRIESTAD, GK ^{[1
]}

BRANCHAUD, BP ^{[1
]}

机构：

[1] UNIV OREGON,DEPT CHEM,EUGENE,OR 97403

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 39期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0040-4039(95)01460-Y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pd-catalyzed aryl-enone cyclization of 1 leads to Heck-type non-reductive cyclization product 3 and reductive cyclization product 4. Conditions have been developed to selectively form either 3 or 4 (or more highly functionalized 10 vs 11 or 13 vs 14). The formation of non-reductive cyclization products (3, 11, 14) requires an unusual apparent trans beta-H elimination - some mechanistic possibilities that are consistent with the data are proposed.

引用

页码：7047 / 7050

页数：4

共 50 条

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