PREDICTION OF THE MAXIMAL TOLERATED DOSE (MTD) AND THERAPEUTIC EFFECT OF ANTICANCER DRUGS IN HUMANS - INTEGRATION OF PHARMACOKINETICS WITH PHARMACODYNAMICS AND TOXICODYNAMICS

被引：17
作者：
FUSE, E
KOBAYASHI, T
INABA, M
SUGIYAMA, Y
机构：
[1] SANKYO CO LTD,BIOL RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN
[2] JAPANESE FDN CANC RES,CTR CANC CHEMOTHERAPY,TOSHIMA KU,TOKYO 170,JAPAN
[3] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN
来源：
CANCER TREATMENT REVIEWS | 1995年 / 21卷 / 02期
关键词：
D O I：
10.1016/0305-7372(95)90024-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
[No abstract available]
引用
收藏
页码：133 / 157
页数：25
相关论文
共 69 条
[1]  
BENNETT CL, 1987, CANCER RES, V47, P1952
[2]  
BENOWITZ N, 1974, CLIN PHARMACOL THER, V16, P87
[3]   INTERSPECIES PHARMACOKINETIC SCALING AND THE EVOLUTIONARY-COMPARATIVE PARADIGM [J].
BOXENBAUM, H .
DRUG METABOLISM REVIEWS, 1984, 15 (5-6) :1071-1121
[4]   INTERSPECIES PHARMACOKINETIC SCALING AND THE DEDRICK PLOTS [J].
BOXENBAUM, H ;
RONFELD, R .
AMERICAN JOURNAL OF PHYSIOLOGY, 1983, 245 (06) :R768-R775
[5]   INTERSPECIES SCALING, ALLOMETRY, PHYSIOLOGICAL TIME, AND THE GROUND PLAN OF PHARMACOKINETICS [J].
BOXENBAUM, H .
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1982, 10 (02) :201-225
[6]  
COLLINS JM, 1986, CANCER TREAT REP, V70, P73
[7]   PHARMACOLOGICALLY GUIDED PHASE-I CLINICAL-TRIALS BASED UPON PRECLINICAL DRUG DEVELOPMENT [J].
COLLINS, JM ;
GRIESHABER, CK ;
CHABNER, BA .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1990, 82 (16) :1321-1326
[8]  
DEDRICK RL, 1970, CANCER CHEMOTH REP 1, V54, P95
[9]   ANIMAL SCALE-UP [J].
DEDRICK, RL .
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1973, 1 (05) :435-460
[10]   IN-VITRO-IN-VIVO CORRELATION OF DRUG-METABOLISM - DEAMINATION OF 1-BETA-D-ARABINOFURANOSYLCYTOSINE [J].
DEDRICK, RL ;
FORRESTER, DD ;
HO, DHW .
BIOCHEMICAL PHARMACOLOGY, 1972, 21 (01) :1-+
1234567