METHOTREXATE SERUM BINDING IN RHEUMATOID-ARTHRITIS

被引：0
|
作者：
CLAUDEPIERRE, P
URIEN, S
CHEVALIER, X
CHASSANY, O
LARGETPIET, B
TILLEMENT, JP
机构：
[1] UNIV PARIS 12,FAC MED,PHARMACOL LAB,F-94010 CRETEIL,FRANCE
[2] INSERM,PARIS,FRANCE
[3] HOP HENRI MONDOR,SERV CLIN RHUMATOL,F-94010 CRETEIL,FRANCE
来源：
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS | 1994年 / 32卷 / 03期
关键词：
RHEUMATOID ARTHRITIS; METHOTREXATE; PLASMA BINDING;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The serum binding of methotrexate was determined by equilibrium dialysis using radiolabelled methotrexate. Methotrexate was only albumin-bound in serum. The binding was 46% in controls versus 42% in rheumatoid arthritis and 44% in cancer. Serum binding was significantly decreased by salicylate and high concentration of naproxen. Hypoalbuminemia and concomitant administration of salicylate or naproxen may influence methotrexate toxicity.
引用
收藏
页码：113 / 115
页数：3
相关论文
共 50 条
  • [41] METHOTREXATE IN RHEUMATOID-ARTHRITIS - AN UPDATE
    MILLER, DR
    LETENDRE, PW
    DEJONG, DJ
    FIECHTNER, JJ
    PHARMACOTHERAPY, 1986, 6 (04): : 170 - 178
  • [42] SEIZURE AND METHOTREXATE THERAPY IN RHEUMATOID-ARTHRITIS
    THOMAS, E
    LEROUX, JL
    HELLIER, JP
    BLOTMAN, F
    JOURNAL OF RHEUMATOLOGY, 1993, 20 (09) : 1632 - 1632
  • [43] METHOTREXATE - MECHANISM OF ACTION IN RHEUMATOID-ARTHRITIS
    SEGAL, R
    YARON, M
    TARTAKOVSKY, B
    SEMINARS IN ARTHRITIS AND RHEUMATISM, 1990, 20 (03) : 190 - 199
  • [44] METHOTREXATE THERAPY FOR JUVENILE RHEUMATOID-ARTHRITIS
    FELDMAN, BM
    SILVERMAN, ED
    JOURNAL OF PEDIATRICS, 1991, 118 (06): : 992 - 992
  • [45] ORAL METHOTREXATE IN THE TREATMENT OF RHEUMATOID-ARTHRITIS
    LICHTENSTEIN, JR
    CLINICAL RESEARCH, 1983, 31 (02): : A652 - A652
  • [46] METHOTREXATE IN OLDER PATIENTS WITH RHEUMATOID-ARTHRITIS
    POOLE, P
    YEOMAN, S
    CAUGHEY, D
    BRITISH JOURNAL OF RHEUMATOLOGY, 1992, 31 (12): : 860 - 860
  • [47] DELAYED METHOTREXATE PNEUMONITIS IN RHEUMATOID-ARTHRITIS
    POUREL, J
    GUILLEMIN, F
    FENER, P
    WEBANCK, L
    BENE, MC
    DELORME, N
    JOURNAL OF RHEUMATOLOGY, 1991, 18 (02) : 303 - 304
  • [48] METHOTREXATE PHARMACOKINETICS IN PATIENTS WITH RHEUMATOID-ARTHRITIS
    SINNETT, MJ
    GROFF, GD
    RADDATZ, DA
    FRANCK, WA
    BERTINO, JS
    JOURNAL OF RHEUMATOLOGY, 1989, 16 (06) : 745 - 748
  • [49] METHOTREXATE EFFICACY IN THERAPY OF RHEUMATOID-ARTHRITIS
    AGADZHANYAN, RN
    TERAPEVTICHESKII ARKHIV, 1987, 59 (01) : 118 - 121
  • [50] METHOTREXATE TREATMENT POLICY IN RHEUMATOID-ARTHRITIS
    NOSKOV, SM
    KLINICHESKAYA MEDITSINA, 1994, 72 (04): : 49 - 51
12345