METHOTREXATE SERUM BINDING IN RHEUMATOID-ARTHRITIS

被引：0
|
作者：
CLAUDEPIERRE, P
URIEN, S
CHEVALIER, X
CHASSANY, O
LARGETPIET, B
TILLEMENT, JP
机构：
[1] UNIV PARIS 12,FAC MED,PHARMACOL LAB,F-94010 CRETEIL,FRANCE
[2] INSERM,PARIS,FRANCE
[3] HOP HENRI MONDOR,SERV CLIN RHUMATOL,F-94010 CRETEIL,FRANCE
来源：
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS | 1994年 / 32卷 / 03期
关键词：
RHEUMATOID ARTHRITIS; METHOTREXATE; PLASMA BINDING;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The serum binding of methotrexate was determined by equilibrium dialysis using radiolabelled methotrexate. Methotrexate was only albumin-bound in serum. The binding was 46% in controls versus 42% in rheumatoid arthritis and 44% in cancer. Serum binding was significantly decreased by salicylate and high concentration of naproxen. Hypoalbuminemia and concomitant administration of salicylate or naproxen may influence methotrexate toxicity.
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页码：113 / 115
页数：3
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