VARIATION AND INVITRO SPLICING OF GROUP-I INTRONS IN RIBOSOMAL-RNA GENES OF PNEUMOCYSTIS-CARINII

被引：72

作者：

LIU, Y ^{[1
]}

LEIBOWITZ, MJ ^{[1
]}

机构：

[1] UMDNJ,ROBERT WOOD JOHNSON MED SCH,DEPT MOLEC GENET & MICROBIOL,675 HOES LANE,PISCATAWAY,NJ 08854

来源：

NUCLEIC ACIDS RESEARCH | 1993年 / 21卷 / 10期

关键词：

D O I：

10.1093/nar/21.10.2415

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sequences of the rRNA genes of Pneumocystis carinii from rat and human sources demonstrate three distinct genotypes based on the group I introns present in these genes. One rat isolate (Pc1) contains such introns in its 16S and 26S rRNA genes, while another rat isolate (Pc2) and a human isolate (Pc3) only contain an intron in the 26S rRNA gene. The four introns all catalyze their own excision from RNA transcripts, and this reaction is inhibited by the anti-pneumocystis drug pentamidine and its analogues. Although they differ in sequence, they are more similar to one another than to group I introns found in other eukaryotic microbes.

引用

页码：2415 / 2421

页数：7

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