COMBRETATROPONES - HYBRIDS OF COMBRETASTATIN AND COLCHICINE - SYNTHESIS AND BIOCHEMICAL EVALUATION

被引：18

作者：

ANDRES, CJ

BERNARDO, JE

YAN, Q

HASTIE, SB

MACDONALD, TL

机构：

[1] UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22901

[2] SUNY BINGHAMTON,DEPT CHEM,BINGHAMTON,NY 13901

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)81230-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological evaluation is presented for a new class of tubulin-targeting agents, termed ''combretatropones,'' that incorporate the 1,2-diaryl ethane nucleus of combretastatin and the tropone moiety of colchicine.

引用

页码：565 / 570

页数：6

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