SOLUTION STRUCTURE OF THE SH3 DOMAIN OF SRC AND IDENTIFICATION OF ITS LIGAND-BINDING SITE

被引：304

作者：

YU, HT

ROSEN, MK

SHIN, TB

SEIDELDUGAN, C

BRUGGE, JS

SCHREIBER, SL

机构：

[1] HARVARD UNIV,DEPT CHEM,CAMBRIDGE,MA 02138

[2] ARIAD PHARMACEUT INC,CAMBRIDGE,MA 02139

来源：

SCIENCE | 1992年 / 258卷 / 5088期

关键词：

D O I：

10.1126/science.1280858

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Src homology 3 (SH3) region is a protein domain of 55 to 75 amino acids found in many cytoplasmic proteins, including those that participate in signal transduction pathways. The solution structure of the SH3 domain of the tyrosine kinase Src was determined by multidimensional nuclear magnetic resonance methods. The molecule is composed of two short three-stranded anti-parallel beta sheets packed together at approximately right angles. Studies of the SH3 domain bound to proline-rich peptide ligands revealed a hydrophobic binding site on the surface of the protein that is lined with the side chains of conserved aromatic amino acids.

引用

页码：1665 / 1668

页数：4

共 50 条

[41] Solution structure of the first SH3 domain of human vinexin and its interaction with vinculin peptides
Zhang, Jiahai
Li, Xiang
Yao, Bo
Shen, Weiqun
Sun, Hongbin
Xu, Chao
Wu, Jihui
Shi, Yunyu
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 357 (04) : 931 - 937
[42] SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE C-GAMMA
KOHDA, D
HATANAKA, H
ODAKA, M
MANDIYAN, V
ULLRICH, A
SCHLESSINGER, J
INAGAKI, F
CELL, 1993, 72 (06) : 953 - 960
[43] The impact of oncogenic mutations of the viral Src kinase on the structure and stability of the SH3 domain
Carmen Salinas-Garcia, M.
Plaza-Garrido, Marina
Camara-Artigas, Ana
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2021, 77 : 854 - 866
[44] IDENTIFICATION OF SRC, FYN, AND LYN-SH3 BINDING-PROTEINS - IMPLICATIONS FOR A FUNCTION OF SH3 DOMAINS
WENG, ZG
THOMAS, SM
RICKLES, RJ
TAYLOR, JA
BRAUER, AW
SEIDELDUGAN, C
MICHAEL, WM
DREYFUSS, G
BRUGGE, JS
MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (07) : 4509 - 4521
[45] Intertwined dimeric structure for the SH3 domain of the c-Src tyrosine kinase induced by polyethylene glycol binding
Camara-Artigas, Ana
Martin-Garcia, Jose M.
Morel, Bertrand
Ruiz-Sanz, Javier
Luque, Irene
FEBS LETTERS, 2009, 583 (04): : 749 - 753
[46] Synthesis and evaluation of conformationally constrained peptide analogues as the Src SH3 domain binding ligands
Tiwari, Rakesh
Brown, Alex
Narramaneni, Seetha
Sun, Gongqin
Parang, Keykavous
BIOCHIMIE, 2010, 92 (09) : 1153 - 1163
[47] HIGH-RESOLUTION CRYSTAL-STRUCTURE OF A CRK SH3 DOMAIN WITH ITS SPECIFIC LIGAND
WU, XD
KNUDSON, BS
FELLER, SM
HANAFUSA, H
KURIYAN, J
PROTEIN ENGINEERING, 1995, 8 : 38 - 38
[48] Solution Structure of the PAS Domain of a Thermophilic YybT Protein Homolog Reveals a Potential Ligand-binding Site
Tan, Edward
Rao, Feng
Pasunooti, Swathi
Thi Huong Pham
Soehano, Ishin
Turner, Mark S.
Liew, Chong Wai
Lescar, Julien
Pervushin, Konstantin
Liang, Zhao-Xun
JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (17) : 11949 - 11959
[49] The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence
Grabs, D
Slepnev, VI
Zhou, SY
David, C
Lynch, M
Cantley, LC
DeCamilli, P
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (20) : 13419 - 13425
[50] Exploring the binding site structure of the PPARγ ligand-binding domain by computational solvent mapping
Sheu, SH
Kaya, T
Waxman, DJ
Vajda, S
BIOCHEMISTRY, 2005, 44 (04) : 1193 - 1209

← 1 2 3 4 5 →