Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus

被引：2

作者：

Manzke, Pedro ^{[1
,2
]}

Grippe, Talyta ^{[1
,2
]}

Tavares, Georgia L. ^{[1
]}

Leal, Lucas C. ^{[1
]}

Roze, Emmanuel ^{[3
,4
]}

Apartis, Emmanuelle ^{[3
,5
]}

Dias, Ronaldo Maciel ^{[1
]}

Ferreira, Andre G. F. ^{[1
]}

机构：

[1] Inst Hosp Base Dist Fed, Dept Neurol, Brasilia, DF, Brazil

[2] Ctr Univ Brasilia UNICEUB, Med Dept, Brasilia, DF, Brazil

[3] Hop La Pitie Salpetriere, AP HP, Dept Neurol, Paris, France

[4] Sorbonne Univ, Fac Med, Inst Cerveau & Moelle Epiniere, Paris, France

[5] St Antoine Hosp, AP HP, Dept Neurophysiol, Paris, France

来源：

TREMOR AND OTHER HYPERKINETIC MOVEMENTS | 2018年 / 8卷

关键词：

Anti-glutamic acid decarboxylase antibodies; stiff person syndrome; autoimmunity; myoclonus; epilepsy;

D O I：

10.7916/D8NK4XVP

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: The clinical spectrum of anti-glutamic acid decarboxylase (GAD) antibody-associated neurologic syndromes is expanding, with focal, generalized, and atypical forms. Case Report: We describe a 59-year-old female showing continuous right lower limb air:A:Joints and mild encephalopathy. These symptoms started 2 weeks prior to evaluation. The patient had great improvement with intravenous steroids. An autoantibody panel was positive for anti-GAD. Discussion: Various clinical manifestations, including myoclonus, may relate to anti-GAD antibodies. The treatment options available include symptomatic drugs, intravenous immunoglObulin, steroids, and other immunosuppressant agents.

引用

页数：3

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