THE DEVELOPMENT OF A CATECHOL ENZYME ELECTRODE AND ITS POSSIBLE USE FOR THE DIAGNOSIS AND MONITORING OF NEURAL CREST TUMORS

被引：39
作者：
TILLYER, CR
GOBIN, PT
机构：
[1] Department of Chemical Pathology, Royal Marsden Hospital, London, SW3 6JJ, Fulham Road
来源：
BIOSENSORS & BIOELECTRONICS | 1991年 / 6卷 / 07期
关键词：
CATECHOL; POLYPHENOL OXIDASE; ENZYME ELECTRODE; PHEOCHROMOCYTOMA; NEUROBLASTOMA; URINE;
D O I：
10.1016/0956-5663(91)80021-O
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
A catechol enzyme electrode is described, in which a Clark-type oxygen electrode is coupled to immobilised polyphenol oxidase in albumin cross linked with glutaraldehyde on a dialysis membrane. Electrode calibration, response time, pH response profile, stability, detection limit and selectivity are evaluated and the feasibility of using the electrode for the measurement of catecholamines in the urine of patients with neural crest tumours is assessed.
引用
收藏
页码：569 / 573
页数：5
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