INVITRO EFFECT OF DIMETHOATE ON THE ACTIVITY OF TRYPTOPHAN-PYRROLASE IN RAT-LIVER

被引：1

作者：

HASSAN, AAM ^{[1
]}

ELSEWEDY, SM ^{[1
]}

MINATOGAWA, Y ^{[1
]}

KIDO, R ^{[1
]}

机构：

[1] WAKAYAMA MED COLL,DEPT BIOCHEM,WAKAYAMA,JAPAN

来源：

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES | 1991年 / 26卷 / 03期

关键词：

DIMETHOATE; TRYPTOPOHAN PYRROLASE; TOTAL-FORM; HOLO-FORM;

D O I：

10.1080/03601239109372739

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Total and holo-enzyme activities of tryptophan 2,3-dioxygenase were measured in vitro in the presence and absence of the organophosphorous insecticide, dimethoate. Addition of dimethoate to the reaction mixture decreased the activities of both total and holo-forms. Total and holo-enzyme activities were decreased by 34% and 26%, respectively, by 1 mM dimethoate. On the other hand, 5 mM dimethoate resulted in 56% and 34% inhibition to total and holo-enzyme activities, respectively. Lineweaver-Burk plot of the total-enzyme activity at different tryptophan concentration in the presence of 2 mM dimethoate gave uncompetitive type of inhibition.

引用

页码：333 / 338

页数：6

共 3 条

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