PRENATAL ONTOGENY OF GROWTH-HORMONE RELEASING HORMONE EXPRESSION IN RAT HYPOTHALAMUS

被引：12
|
作者：
BURGUNDER, JM [1 ]
机构：
[1] UNIV BERN,NEUROL KLIN,NEUROMORPHOL LAB,CH-3000 BERN,SWITZERLAND
来源：
DEVELOPMENTAL NEUROSCIENCE | 1991年 / 13卷 / 06期
关键词：
GROWTH HORMONE-RELEASING HORMONE; HYBRIDIZATION HISTOCHEMISTRY; ONTOGENY; HYPOTHALAMUS; RAT;
D O I：
10.1159/000112190
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The prenatal development of growth hormone-releasing hormone (GHRH) gene expression was studied in rat hypothalamus using hybridization histochemistry. Two populations of neurons expressing the GHRH gene were found and they had a different pattern of development. Neurons in the arcuate nucleus first expressed GHRH on E16 and 4 days later an adult-like pattern was found. Few neurons along the laterodorsal aspect of the ventromedial hypothalamic nucleus expressed GHRH on E17, with a subsequent increase of expression over the next days. On the day before birth, adult-like patterns were seen. These results demonstrate the differential regulation of GHRH gene expression in the rat hypothalamus.
引用
收藏
页码：397 / 402
页数：6
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