PRENATAL ONTOGENY OF GROWTH-HORMONE RELEASING HORMONE EXPRESSION IN RAT HYPOTHALAMUS

被引：12

作者：

BURGUNDER, JM ^{[1
]}

机构：

[1] UNIV BERN,NEUROL KLIN,NEUROMORPHOL LAB,CH-3000 BERN,SWITZERLAND

来源：

DEVELOPMENTAL NEUROSCIENCE | 1991年 / 13卷 / 06期

关键词：

GROWTH HORMONE-RELEASING HORMONE; HYBRIDIZATION HISTOCHEMISTRY; ONTOGENY; HYPOTHALAMUS; RAT;

D O I：

10.1159/000112190

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The prenatal development of growth hormone-releasing hormone (GHRH) gene expression was studied in rat hypothalamus using hybridization histochemistry. Two populations of neurons expressing the GHRH gene were found and they had a different pattern of development. Neurons in the arcuate nucleus first expressed GHRH on E16 and 4 days later an adult-like pattern was found. Few neurons along the laterodorsal aspect of the ventromedial hypothalamic nucleus expressed GHRH on E17, with a subsequent increase of expression over the next days. On the day before birth, adult-like patterns were seen. These results demonstrate the differential regulation of GHRH gene expression in the rat hypothalamus.

引用

页码：397 / 402

页数：6

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