ELEVATED CIRCULATING TUMOR-NECROSIS-FACTOR LEVELS IN ALZHEIMERS-DISEASE

被引：433

作者：

FILLIT, H

DING, W

BUEE, L

KALMAN, J

ALTSTIEL, L

LAWLOR, B

WOLFKLEIN, G

机构：

[1] MT SINAI MED CTR,RITTER DEPT GERIATR,NEW YORK,NY 10029

[2] MT SINAI MED CTR,FISHBERG CTR NEUROBIOL,DEPT MED,NEW YORK,NY 10029

[3] MT SINAI MED CTR,FISHBERG CTR NEUROBIOL,DEPT PSYCHIAT,NEW YORK,NY 10029

[4] MT SINAI MED CTR,ALZHEIMERS DIS RES CTR,NEW YORK,NY 10029

[5] PARKER JEWISH GERIATR CTR,NEW HYDE PK,NY

[6] INSERM,U156,F-59045 LILLE,FRANCE

来源：

NEUROSCIENCE LETTERS | 1991年 / 129卷 / 02期

关键词：

ALZHEIMERS DISEASE; CYTOKINE; TUMOR NECROSIS FACTOR; IMMUNOPATHOLOGY;

D O I：

10.1016/0304-3940(91)90490-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent investigations have demonstrated a local inflammatory response in Alzheimer's disease (AD), including microglia and cytokines. Levels of the cytokine tumor necrosis factor-alpha (TNF-alpha) in sera from patients with AD and age-matched controls were measured by an enzyme-linked immunoassay and a cytotoxicity bioassay. Significantly elevated levels of TNF were found in AD sera compared to controls. Elevated circulating TNF may be derived from the local CNS inflammatory reaction in AD, and may account for some systemic manifestations of AD such as weight loss. Future studies may determine if, in the absence of complicating disorders which may elevate TNF, circulating TNF could be a marker of AD inflammatory activity.

引用

页码：318 / 320

页数：3

共 17 条

[1] IMMUNOCHEMICAL IDENTIFICATION OF THE SERINE PROTEASE INHIBITOR ALPHA-1-ANTICHYMOTRYPSIN IN THE BRAIN AMYLOID DEPOSITS OF ALZHEIMERS-DISEASE [J].