SYNTHESIS, STEREOCHEMISTRY, AND BIOLOGICAL PROPERTIES OF THE DEPIGMENTING AGENTS, MELANOSTATIN, FELDAMYCIN AND ANALOGS

被引:17
作者
IMAE, K
KAMACHI, H
YAMASHITA, H
OKITA, T
OKUYAMA, S
TSUNO, T
YAMASAKI, T
SAWADA, Y
OHBAYASHI, M
NAITO, T
OKI, T
机构
[1] Bristol-Myers Squibb Research Institute, Meguro-ku, Tokyo 153
关键词
ACID; DERIVATIVES; FR900490; FUNGUS;
D O I
10.7164/antibiotics.44.76
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Syntheses of melanostatin and feldamycin have been completed from L-serine and L-theronine, respectively, and the configuration of unknown asymmetric carbons determined. Feldamycin analogs have also been prepared and the L-tryptophyl analog was the most potent in the depigmentation of Streptomyces bikiniensis and B16 melanoma cells.
引用
收藏
页码:76 / 85
页数:10
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