SYNTHESIS, STEREOCHEMISTRY, AND BIOLOGICAL PROPERTIES OF THE DEPIGMENTING AGENTS, MELANOSTATIN, FELDAMYCIN AND ANALOGS

被引：17
作者：
IMAE, K
KAMACHI, H
YAMASHITA, H
OKITA, T
OKUYAMA, S
TSUNO, T
YAMASAKI, T
SAWADA, Y
OHBAYASHI, M
NAITO, T
OKI, T
机构：
[1] Bristol-Myers Squibb Research Institute, Meguro-ku, Tokyo 153
来源：
JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 01期
关键词：
ACID; DERIVATIVES; FR900490; FUNGUS;
D O I：
10.7164/antibiotics.44.76
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Syntheses of melanostatin and feldamycin have been completed from L-serine and L-theronine, respectively, and the configuration of unknown asymmetric carbons determined. Feldamycin analogs have also been prepared and the L-tryptophyl analog was the most potent in the depigmentation of Streptomyces bikiniensis and B16 melanoma cells.
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页码：76 / 85
页数：10
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