IDENTIFICATION OF 6-HYDROXYMELATONIN IN NORMAL HUMAN-URINE BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY

被引：12
作者：
SISAK, ME
MARKEY, SP
COLBURN, RW
ZAVADIL, AP
KOPIN, IJ
机构：
[1] Laboratory of Clinical Science National Institute of Mental Health Bethesda
来源：
LIFE SCIENCES | 1979年 / 25卷 / 09期
关键词：
D O I：
10.1016/0024-3205(79)90526-5
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The major melatonin metabolite, 6-hydroxymelatonin, has been identified in normal human urine by gas chromatography-mass spectrometry (gc-ms) after rapid acid hydrolysis, extraction, and derivatization. An estimate of the amount detected (approximately 20 ng/ml) is consistent with calculated rates of melatonin synthesis and turnover. © 1979.
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页码：803 / 806
页数：4
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