DIFFERENTIAL CHANGES IN SEROTONIN 5-HT(1A) AND 5-HT(2) RECEPTOR-BINDING IN PATIENTS WITH CHRONIC-SCHIZOPHRENIA

被引：84

作者：

HASHIMOTO, T

KITAMURA, N

KAJIMOTO, Y

SHIRAI, Y

SHIRAKAWA, O

MITA, T

NISHINO, N

TANAKA, C

机构：

[1] KOBE UNIV,SCH MED,DEPT PSYCHIAT & NEUROL,7-5-1 KUSUNOKI CHO,CHUO KU,KOBE 650,JAPAN

[2] SAISEIKAI NAKATSU HOSP,DEPT PSYCHIAT,OSAKA 530,JAPAN

[3] KOBE UNIV,SCH MED,DEPT PHARMACOL,KOBE 650,JAPAN

来源：

PSYCHOPHARMACOLOGY | 1993年 / 112卷 / 01期

关键词：

SEROTONIN; SEROTONIN(1A) (5-HT(1A)) RECEPTOR; SEROTONIN(2) (5-HT(2)) RECEPTOR; SCHIZOPHRENIA; POSTMORTEM BRAIN;

D O I：

10.1007/BF02245005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Serotonin 5-HT1A and 5-HT2 receptors were examined in the postmortem brains of controls and patients with chronic schizophrenia. In the prefrontal cortex from patients with schizophrenia, 5-HT1A receptor binding was increased, while 5-HT2 receptor binding was decreased, when compared to controls. The increased 5-HT1A receptor binding or the decreased 5-HT2 receptor binding was observed in both the patients who had been medicated with neuroleptics at time of death and those who had not, at least 2 months prior to death. Thus, abnormalities of 5-HT receptor subtypes seem to exist in the brains of patients with chronic schizophrenia. 5-HT related agents might be beneficial for the treatment of schizophrenia.

引用

页码：S35 / S39

页数：5

共 43 条

[1] DIFFERENTIAL EFFECT OF SUBCHRONIC TREATMENT WITH VARIOUS NEUROLEPTIC AGENTS ON SEROTONIN2 RECEPTORS IN RAT CEREBRAL-CORTEX [J].