LIPID-PEROXIDATION AND ANTIOXIDANT ENZYMATIC SYSTEMS IN RAT RETINA AS A FUNCTION OF AGE

被引：60

作者：

CASTORINA, C ^{[1
]}

CAMPISI, A ^{[1
]}

DIGIACOMO, C ^{[1
]}

SORRENTI, V ^{[1
]}

RUSSO, A ^{[1
]}

VANELLA, A ^{[1
]}

机构：

[1] UNIV CATANIA,SCH PHARM,INST BIOCHEM,CHAIR BIOCHEM,VIALE ANDREA DORIA 6,I-95100 CATANIA,ITALY

来源：

NEUROCHEMICAL RESEARCH | 1992年 / 17卷 / 06期

关键词：

LIPOPEROXIDATION; ANTIOXIDANT ENZYMATIC SYSTEMS; RETINA; AGING;

D O I：

10.1007/BF00968789

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present study, we have assayed the enzymatic activity of Cu,Zn-SOD, Mn-SOD, GSH-Px, GSH-Red, Cat, and G6PD in rat retina as a function of age. Conjugated diene levels and MDA formation were also determined. The conjugated diene levels in rat retina were found to increase significantly with age, accompanied by a marked decrease in GSH-Px and Cat activities. No age-related change in MDA levels and in GSH-Red and G6PD activity was found, whereas a significant increase in SOD activity was observed between 1 and 4 months. Decreased GSH-Px and Cat activity is related to increased lipid peroxidation with age.

引用

页码：599 / 604

页数：6

共 58 条

[41] DO MITOCHONDRIA PRODUCE OXYGEN RADICALS INVIVO [J].

NOHL, H ;

HEGNER, D .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1978, 82 (02) :563-567

[42] ASSAY FOR LIPID PEROXIDES IN ANIMAL-TISSUES BY THIOBARBITURIC ACID REACTION [J].

OHKAWA, H ;

OHISHI, N ;

YAGI, K .

ANALYTICAL BIOCHEMISTRY, 1979, 95 (02) :351-358

[43]

Pacer Z, 1965, EXPERIENTIA, V21, P19

[44]

PAGLIA DE, 1967, J LAB CLIN MED, V70, P158

[45]

Parrish J.A., 1978, UVA BIOL EFFECTS ULT

[46]

RAO NA, 1985, INVEST OPHTH VIS SCI, V26, P1778

[47] GLUTATHIONE PEROXIDASE IN SOME OCULAR TISSUES [J].

REIM, M ;

HEUVELS, B ;

CATTEPOEL, H .

OPHTHALMIC RESEARCH, 1974, 6 (2-4) :228-234

[48] FREE-RADICALS FROM EUMELANINS - QUANTUM YIELDS AND WAVELENGTH DEPENDENCE [J].

SARNA, T ;

SEALY, RC .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1984, 232 (02) :574-578

[49]

SICKEL W, 1972, RETINAL METABOLISM D, P667

[50]

STEVENS JB, 1977, J BIOL CHEM, V252, P3509

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