LIPID-PEROXIDATION AND ANTIOXIDANT ENZYMATIC SYSTEMS IN RAT RETINA AS A FUNCTION OF AGE

被引：60
作者：
CASTORINA, C [1 ]
CAMPISI, A [1 ]
DIGIACOMO, C [1 ]
SORRENTI, V [1 ]
RUSSO, A [1 ]
VANELLA, A [1 ]
机构：
[1] UNIV CATANIA,SCH PHARM,INST BIOCHEM,CHAIR BIOCHEM,VIALE ANDREA DORIA 6,I-95100 CATANIA,ITALY
来源：
NEUROCHEMICAL RESEARCH | 1992年 / 17卷 / 06期
关键词：
LIPOPEROXIDATION; ANTIOXIDANT ENZYMATIC SYSTEMS; RETINA; AGING;
D O I：
10.1007/BF00968789
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the present study, we have assayed the enzymatic activity of Cu,Zn-SOD, Mn-SOD, GSH-Px, GSH-Red, Cat, and G6PD in rat retina as a function of age. Conjugated diene levels and MDA formation were also determined. The conjugated diene levels in rat retina were found to increase significantly with age, accompanied by a marked decrease in GSH-Px and Cat activities. No age-related change in MDA levels and in GSH-Red and G6PD activity was found, whereas a significant increase in SOD activity was observed between 1 and 4 months. Decreased GSH-Px and Cat activity is related to increased lipid peroxidation with age.
引用
收藏
页码：599 / 604
页数：6
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