SYNDROME OF INAPPROPRIATE SECRETION OF ANTIDIURETIC-HORMONE AFTER INFUSIONAL VINCRISTINE

被引：16

作者：

ESCURO, RS ^{[1
]}

ADELSTEIN, DJ ^{[1
]}

CARTER, SG ^{[1
]}

机构：

[1] CLEVELAND METROPOLITAN GEN HOSP,DEPT MED,DIV HEMATOL ONCOL,CLEVELAND,OH 44109

来源：

CLEVELAND CLINIC JOURNAL OF MEDICINE | 1992年 / 59卷 / 06期

关键词：

INAPPROPRIATE ADH SYNDROME; VINCRISTINE; DOXORUBICIN; DEXAMETHASONE; MULTIPLE MYELOMA;

D O I：

10.3949/ccjm.59.6.643

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 77-year-old woman with refractory multiple myeloma was treated with a 4-day continuous intravenous infusion of vincristine and doxorubicin and 4 days of oral dexamethasone. Nine days after her second cycle she presented with lethargy and weakness associated with hyponatremia. Evaluation revealed the syndrome of inappropriate secretion of antidiuretic hormone, which was attributed to the vincristine infusion. After normal serum sodium levels returned, further doxorubicin and dexamethasone chemotherapy without vincristine did not produce this complication.

引用

页码：643 / 644

页数：2