EBV-Associated Cancer and Autoimmunity: Searching for Therapies

被引：17

作者：

Capone, Giovanni ^{[1
]}

Fasano, Candida ^{[1
]}

Lucchese, Guglielmo ^{[2
]}

Calabro, Michele ^{[1
]}

Kanduc, Darja ^{[1
]}

机构：

[1] Univ Bari, Dept Biosci Biotechnol & Biopharmaceut, I-70126 Bari, Italy

[2] Free Univ Berlin, Brain & Language Lab, D-14195 Berlin, Germany

来源：

VACCINES | 2015年 / 3卷 / 01期

关键词：

EBV EBNA1; cancer; autoimmunity; peptide matching; low-similarity peptides; anti-EBV vaccine; peptide-therapy;

D O I：

10.3390/vaccines3010074

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Epstein-Barr virus (EBV) infects B-, T-, and NK cells and has been associated not only with a wide range of lymphoid malignancies but also with autoimmune diseases such as lupus erythematosus, rheumatoid arthritis and, in particular, multiple sclerosis. Hence, effective immunotherapeutic approaches to eradicate EBV infection might overthrow cancer and autoimmunity incidence. However, currently no effective anti-EBV immunotherapy is available. Here we use the concept that protein immunogenicity is allocated in rare peptide sequences and search the Epstein-Barr nuclear antigen 1 (EBNA1) sequence for peptides unique to the viral protein and absent in the human host. We report on a set of unique EBV EBNA1 peptides that might be used in designing peptide-based therapies able to specifically hitting the virus or neutralizing pathogenic autoantibodies.

引用

页码：74 / 89

页数：16

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