SPECIFIC NON-OPIATE RECEPTORS FOR BETA-ENDORPHIN

被引:441
作者
HAZUM, E
CHANG, KJ
CUATRECASAS, P
机构
[1] Department of Molecular Biology, Wellcome Research Laboratories, Research Triangle Park
关键词
D O I
10.1126/science.224457
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Iodinated βH-[2-D-alanine]endorphin exhibits specific binding to cultured human lymphocytes. The binding is inhibited by low concentrations of β-endorphin and its D-alanine2 derivative, but is not affected by opiate agonists and antagonists, or by enkephalin analogs, β-lipotropin, adrenocorticotrophic hormone, or α-melanocyte- stimulating hormone; this suggests the existence of a specific, nonopiate binding site (receptor) for β-endorphin. The carboxy-terminal region of β-endorphin is essential for this binding activity, since α-endorphin is not active. β-Endorphin may be a circulating hormone with peripheral physiological effects that are not primarily mediated through interactions with opiate or enkephalin receptors.
引用
收藏
页码:1033 / 1035
页数:3
相关论文
共 18 条
[1]   ENDORPHINS - PROFOUND BEHAVIORAL-EFFECTS IN RATS SUGGEST NEW ETIOLOGICAL FACTORS IN MENTAL-ILLNESS [J].
BLOOM, F ;
SEGAL, D ;
LING, N ;
GUILLEMIN, R .
SCIENCE, 1976, 194 (4265) :630-632
[2]  
CHANG KJ, 1979, J BIOL CHEM, V254, P2610
[3]  
CHANG KJ, 1979, MOL PHARMACOL, V16, P91
[4]   OPIOID ACTIVITY OF A PEPTIDE, BETA-LIPOTROPIN-(61-91), DERIVED FROM BETA-LIPOTROPIN [J].
COX, BM ;
GOLDSTEIN, A ;
LI, CH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (06) :1821-1823
[5]  
GAVIN JR, 1973, J BIOL CHEM, V248, P2202
[6]   INDUCTION OF EXCESSIVE GROOMING IN RAT BY FRAGMENTS OF LIPOTROPIN [J].
GISPEN, WH ;
WIEGANT, VM ;
BRADBURY, AF ;
HULME, EC ;
SMYTH, DG ;
SNELL, CR ;
DEWIED, D .
NATURE, 1976, 264 (5588) :794-795
[7]  
HAZUM E, 1979, J BIOL CHEM, V254, P1765
[8]   MORPHINE AND BETA-ENDORPHIN INFLUENCE SECRETION OF ENDOCRINE PANCREAS [J].
IPP, E ;
DOBBS, R ;
UNGER, RH .
NATURE, 1978, 276 (5684) :190-191
[9]   C-FRAGMENT OF BETA-LIPOTROPIN - ENDOGENOUS NEUROLEPTIC OR ANTIPSYCHOTOGEN [J].
JACQUET, YF ;
MARKS, N .
SCIENCE, 1976, 194 (4265) :632-635
[10]  
JEFFCOATE WJ, 1978, LANCET, V2, P119