FUS - A SYSTEM TO SIMULATE CONFORMATIONAL-CHANGES IN BIOLOGICAL MACROMOLECULES

被引：0
|
作者：
MAJOR, F
FELDMANN, R
LAPALME, G
CEDERGREN, R
机构：
[1] UNIV MONTREAL,DEPT BIOCHIM,CASE POSTALE 6128,SUCCURSALE A,MONTREAL H3C 3J7,QUEBEC,CANADA
[2] UNIV MONTREAL,DEPT INFORMAT & RECH OPERAT,MONTREAL H3C 3J7,QUEBEC,CANADA
[3] NIH,DIV COMP RES & TECHNOL,BETHESDA,MD 20892
来源：
COMPUTER APPLICATIONS IN THE BIOSCIENCES | 1988年 / 4卷 / 04期
关键词：
Biological Materials - Computer Simulation - Computer Software - Molecules - Computer Simulation - Nucleic Acids - Structure;
D O I：
暂无
中图分类号：
TP39 [计算机的应用];
学科分类号：
081203 ; 0835 ;
摘要：
In order to study the dynamics of protein and nucleic acid conformations, a molecular folding - unfolding system (FUS written in Lisp) has been developed. Secondary structure features of protein and nucleic acids are graphically represented by cubes in a modified 'Blocks World' paradigm. Modeling of protein and nucleic acid unfolding (denaturation) and folding of their three-dimensional structure is possible by the use of high level 'block' operators which allow displacement of these structural features in space. Due to the flexible nature of this program, FUS is a useful tool for the rapid evaluation of user-defined rules governing conformational changes.
引用
收藏
页码：445 / 451
页数：7
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