TRISOMY-12 AND K-RAS-2 AMPLIFICATION IN HUMAN OVARIAN-TUMORS

被引：36
作者：
YANGFENG, TL
LI, SB
LEUNG, WY
CARCANGIU, ML
SCHWARTZ, PE
机构：
[1] NATL YANG MING MED COLL,VET GEN HOSP,DEPT OBSTET & GYNECOL,TAIPEI,TAIWAN
[2] YALE UNIV,SCH MED,DEPT PATHOL,NEW HAVEN,CT 06510
[3] YALE UNIV,SCH MED,DEPT OBSTET & GYNECOL,NEW HAVEN,CT 06510
来源：
INTERNATIONAL JOURNAL OF CANCER | 1991年 / 48卷 / 05期
关键词：
D O I：
10.1002/ijc.2910480508
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cytogenetic analysis was performed on 11 benign and borderline ovarian tumors. Trisomy 12, identified as a sole abnormality in 6 tumors, is likely a specific karyotypic change in different benign and borderline tumors and may well be a primary chromosomal lesion in these tumors. The possible association between amplification of the proto-oncogene K-ras-2 which is located on chromosome 12 and trisomy 12 was investigated. DNA blotting analysis of 64 tumors indicates that trisomy 12 does not seem to be related to K-ras-2 amplification in ovarian tumors. K-ras-2 amplification was observed in 3 high-grade tumors from 3 patients with metastases.
引用
收藏
页码：678 / 681
页数：4
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