CHANGES IN EXPRESSION OF GLUTAMATE-RECEPTOR SUBUNITS FOLLOWING PHOTORECEPTOR DEGENERATION IN THE RD MOUSE RETINA

被引：18
作者：
DUVOISIN, RM
ZHANG, CX
HAMASSAKIBRITTO, DE
BRITTO, LRG
机构：
[1] CORNELL UNIV,GRAD SCH MED SCI,NEUROSCI PROGRAM,NEW YORK,NY 10021
[2] UNIV SAO PAULO,INST BIOMED SCI,DEPT HISTOL & EMBRYOL,BR-05508 SAO PAULO,BRAZIL
[3] UNIV SAO PAULO,INST BIOMED SCI,DEPT PHYS & BIOPHYS,BR-05508 SAO PAULO,BRAZIL
来源：
NEUROSCIENCE LETTERS | 1995年 / 183卷 / 1-2期
关键词：
KAINATE; ALPHA-AMINO-3-HYDROXY-5-METHYL-ISOXASOLE-4-PROPIONATE; GLUTAMATE RECEPTOR; RETINA; PHOTORECEPTOR DEGENERATION; RD MOUSE; IN SITU HYBRIDIZATION;
D O I：
10.1016/0304-3940(94)11120-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of photoreceptor cell degeneration on the expression of nine alpha-amino-3-hydroxy-5-methyl-isoxasole-4-propionate (AMPA)/kainate glutamate receptor subunit genes were investigated in the rd mouse retina by in situ hybridization. All known AMPA/kainate receptor subunits were found to be expressed in normal mouse retina. Following retinal degeneration, the expression of KA-1 was reduced, that of the GluR7 subunit was greatly increased, and that of the other seven subunits were not significantly affected.
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页码：83 / 86
页数：4
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