COMPARATIVE EVALUATION OF THREE DIFFERENT DOSES OF INTRAVENOUS CLONIDINE 1mcg/kg, 2mcg/kg, 3mcg/kg FOR HEMODYNAMIC STUDY IN PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY

CLONIDINE, an imidazoline derivative and alpha-2 agonist causes sedation, anxiolysis, antisalivation, analgesia and provides hemodynamic stability. The aim of our study was to compare the three different doses of intravenous clonidine 1 microgram per kilogram, 2 microgram per kilogram, 3 microgram per kilogram in patients undergoing laparoscopic surgeries. Forty five patients were grouped equally in Group C1, C2, and C3, who received intravenous clonidine 1 microgram per kilogram, 2 microgram per kilogram and 3 microgram per kilogram respectively. Hemodynamic variables, associated complications and side-effects were recorded. It was found that intravenous clonidine 2 microgram per kilogram is the most appropriate dose for attenuating hemodynamic response to pneumoperitonium without any associated significant sideeffects/complications.