IDENTIFICATION OF SELF PEPTIDES BOUND TO PURIFIED HLA-B27

被引：857
作者：
JARDETZKY, TS
LANE, WS
ROBINSON, RA
MADDEN, DR
WILEY, DC
机构：
[1] HARVARD UNIV,HOWARD HUGHES MED INST,CAMBRIDGE,MA 02138
[2] HARVARD UNIV,COMM HIGHER DEGREES BIOPHYS,CAMBRIDGE,MA 02138
[3] HARVARD MICROCHEM FACIL,CAMBRIDGE,MA 02138
来源：
NATURE | 1991年 / 353卷 / 6342期
关键词：
D O I：
10.1038/353326a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A pool of endogenous peptides bound to the human class I MHC molecule, HLA-B27, has been isolated. Microsequence analysis of the pool and of 11 HPLC-purified peptides provides information on the binding specificity of the HLA-B27 molecule. The peptides all seem to be nonamers, seven of which match to protein sequences in a database search. These self peptides derive from abundant cytosolic or nuclear proteins, such as histone, ribosomal proteins, and members of the 90K heat-shock protein family.
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页码：326 / 329
页数：4
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