Synthesis of 3-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propanoic acid - A Functionalized Base Derivative of the & ucleoside Antibiotic Tubercidin

被引：1

作者：

Rosemeyer, Helmut ^{[1
]}

机构：

[1] Univ Osnabruck, Inst Chem, Organ Chem Bioorgan Chem 1, Fachbereich Biol Chem, Barbarastr 6, D-49069 Osnabruck, Germany

来源：

MOLBANK | 2007年 / 04期

关键词：

7-Deazaadenine; Tubercidin; Functionalization;

D O I：

10.3390/M555

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Regioselective N-alkylation of 4-chloro-2-(methylthio)-7H-pyrrolo[2,3-d]pyrimidine (1) with ethyl 3-bromopropionate under liquid-liquid phase-transfer reaction conditions and further saponification of the ester function under formation of compound 3b is described. Subsequent SNAr substitution of the 4-chloro substituent by an amino function and reductive removal of the 2-methylthio group of 3b gives, via 4a, the title compound 4b.

引用

页数：3

共 9 条

[1] ORIENTATION, RECOGNITION, AND PHOTOREACTION OF NUCLEOLIPIDS IN MODEL MEMBRANES [J].