Advances in Degradable Embolic Microspheres: A State of the Art Review

被引：52

作者：

Doucet, Jensen ^{[1
]}

Kiri, Lauren ^{[2
]}

O'Connell, Kathleen ^{[2
]}

Kehoe, Sharon ^{[3
]}

Lewandowski, Robert J. ^{[4
]}

Liu, David M. ^{[5
]}

Abraham, Robert J. ^{[6
]}

Boyd, Daniel ^{[3
]}

机构：

[1] Dalhousie Univ, Sch Biomed Engn, Halifax, NS B3H 4R2, Canada

[2] Fac Dent, Dept Appl Oral Sci, 5981 Univ Ave,POB 15000, Halifax, NS B3H 4R2, Canada

[3] ABK Biomed Inc, Unit 32, 155 Chain Lake Dr, Halifax, NS B3S IB3, Canada

[4] Northwestern Univ, Fienberg Sch Med, Dept Radiol, Div Vasc & Intervent Radiol, Chicago, IL 60611 USA

[5] Univ British Columbia, Dept Radiol, Vancouver, BC V6T 1Z4, Canada

[6] QEII Hlth Sci Ctr, Intervent Radiol & Diagnost Imaging Dept, Room 3316,Halifax Infirm Site,1796 Summer St, Halifax, NS B3H 3A7, Canada

来源：

JOURNAL OF FUNCTIONAL BIOMATERIALS | 2018年 / 9卷 / 01期

关键词：

resorbable; bioresorbable; degradable; microsphere; embolization;

D O I：

10.3390/jfb9010014

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Considerable efforts have been placed on the development of degradable microspheres for use in transarterial embolization indications. Using the guidance of the U.S. Food and Drug Administration (FDA) special controls document for the preclinical evaluation of vascular embolization devices, this review consolidates all relevant data pertaining to novel degradable microsphere technologies for bland embolization into a single reference. This review emphasizes intended use, chemical composition, degradative mechanisms, and pre-clinical safety, efficacy, and performance, while summarizing the key advantages and disadvantages for each degradable technology that is currently under development for transarterial embolization. This review is intended to provide an inclusive reference for clinicians that may facilitate an understanding of clinical and technical concepts related to this field of interventional radiology. For materials scientists, this review highlights innovative devices and current evaluation methodologies (i.e., preclinical models), and is designed to be instructive in the development of innovative/new technologies and evaluation methodologies.

引用

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