SYNTHESES OF FLOSEQUINAN - A NOVEL 4-QUINOLONE SHOWN TO BE USEFUL IN CONGESTIVE-HEART-FAILURE

被引：18

作者：

BIRCH, AM ^{[1
]}

DAVIES, RV ^{[1
]}

MACLEAN, L ^{[1
]}

ROBINSON, K ^{[1
]}

机构：

[1] BOOTS PHARMACEUT,DEPT RES,NOTTINGHAM NG2 3AA,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 04期

关键词：

D O I：

10.1039/p19940000387

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two synthetic routes to flosequinan 1 and flosequinoxan 2 are described in which either ring closure of the beta-keto sulfoxides 12 or 13 with ortho esters or cyclisation of the anilinoacrylates 23, 28 or 29 are the key steps.

引用

页码：387 / 392

页数：6

共 13 条

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