DEVELOPMENT AND PROLIFERATION OF LYMPHOCYTES IN MICE DEFICIENT FOR BOTH INTERLEUKIN-2 AND INTERLEUKIN-4

被引：129
|
作者：
SADLACK, B
KUHN, R
SCHORLE, H
RAJEWSKY, K
MULLER, W
HORAK, I
机构：
[1] UNIV WURZBURG, INST VIROL & IMMUNOBIOL, D-97078 WURZBURG, GERMANY
[2] UNIV COLOGNE, INST GENET, COLOGNE, GERMANY
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 1994年 / 24卷 / 01期
关键词：
INTERLEUKIN-2; INTERLEUKIN-4; DEVELOPMENT AND PROLIFERATION OF LYMPHOCYTES; CYTOKINES; KNOCK-OUT MICE;
D O I：
10.1002/eji.1830240144
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interleukin (IL)-2 and IL-4 are considered as important regulators of growth and differentiation of lymphocytes. We report that in mice made deficient for both IL-2 and IL-4 by gene targeting all major T cell subsets and B cells were normal, indicating that IL-2 and IL-4 are not essential for development of the immune system. Paradoxically, proliferation of T cells was increased in both IL-2- and IL-4-deficient homozygous mice.
引用
收藏
页码：281 / 284
页数：4
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