DEVELOPMENT AND PROLIFERATION OF LYMPHOCYTES IN MICE DEFICIENT FOR BOTH INTERLEUKIN-2 AND INTERLEUKIN-4

被引：129

作者：

SADLACK, B

KUHN, R

SCHORLE, H

RAJEWSKY, K

MULLER, W

HORAK, I

机构：

[1] UNIV WURZBURG, INST VIROL & IMMUNOBIOL, D-97078 WURZBURG, GERMANY

[2] UNIV COLOGNE, INST GENET, COLOGNE, GERMANY

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1994年 / 24卷 / 01期

关键词：

INTERLEUKIN-2; INTERLEUKIN-4; DEVELOPMENT AND PROLIFERATION OF LYMPHOCYTES; CYTOKINES; KNOCK-OUT MICE;

D O I：

10.1002/eji.1830240144

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin (IL)-2 and IL-4 are considered as important regulators of growth and differentiation of lymphocytes. We report that in mice made deficient for both IL-2 and IL-4 by gene targeting all major T cell subsets and B cells were normal, indicating that IL-2 and IL-4 are not essential for development of the immune system. Paradoxically, proliferation of T cells was increased in both IL-2- and IL-4-deficient homozygous mice.

引用

页码：281 / 284

页数：4

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